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Reading: Scientists teach clump of BRAIN CELLS in Petri dish to play cult video game
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Scientists teach 800,000 living brain cells in a petri dish to play cult video game DOOM - after the mini-brain already mastered Pong in a world-first biotech breakthrough.
World News

Scientists teach clump of BRAIN CELLS in Petri dish to play cult video game

Sam Coffey
Last updated: 2026/03/03 at 12:15 PM
Sam Coffey
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4 Min Read
Biotech firm Cortical Labs have trained more than 800,000 living neurons in a petri dish to play the iconic shooter. (Jam Press/Cortical Labs)
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Boffins have pulled off a mind-blowing stunt – teaching a clump of living brain cells to blast their way through cult video game DOOM.

In a world-first that sounds straight out of a sci-fi blockbuster, eggheads at Aussie biotech firm Cortical Labs have trained more than 800,000 living neurons in a petri dish to play the iconic shooter.

The Melbourne-based team first made waves a few years back when their so-called CL1 ‘mini-brain’ managed to run the 1972 arcade classic Pong.

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That alone was enough to raise eyebrows in the tech world.

Now they’ve cranked things up a notch, as reported by What’s the Jam.

Their latest feat sees the same brainy tech tackling DOOM – the fast-paced, monster-packed 3D blaster that defined a generation of gamers.

The CL1 system is made up of real, living neurons grown in a nutrient-rich solution.

These cells spread across a silicon chip, which sends and receives electrical signals.

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Those signals are then translated into actions inside the game.

It might sound like something cooked up in a Hollywood writer’s room, but the system works in a similar way to artificial intelligence.

(Jam Press/Cortical Labs)

The big twist? It needs far less processing power and could have huge implications across the biotech industry.

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Four years on from their Pong breakthrough, the scientists decided to see if their mini-brain could handle something far more demanding.

Enter DOOM.

Brett Kagan, Cortical Labs’ chief science officer, said their earlier Pong success was a “massive milestone” because it proved biological neurons could learn in real time and adapt to achieve a goal.

But it was no quick win.

Brett said: “It took us 18 months with our original hardware and software to get this to work.

“And Pong was much simpler.”

DOOM, on the other hand, was a different beast entirely.

Brett said: “It’s 3D, it has enemies, it needs to explore – it’s an environment, and it’s hard.”

To make it happen, the team had to convert the world of DOOM – its corridors, monsters and mechanics – into electrical impulses the cells could understand.

Those signals allowed the neurons to ‘see’ what was happening and respond.

But they are not exactly esports champions just yet.

Brett added: “Right now, the cells play a lot like a beginner who’s never seen a computer.

“And in all fairness, they haven’t.

“But they show evidence that they can seek out enemies, they can shoot, they can spin.”

The leap from batting a digital ball back and forth in Pong to navigating a chaotic 3D shooter is a huge one.

If a dish of brain cells can learn to survive in DOOM’s demon-filled corridors, the question now is simple – what game will they conquer next?

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